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Misbakhul Munir1, Purwo Sri Rejeki1, Adi Pranoto2, Dewi Ratna Sari3, Nabilah Izzatunnisa4, Rifqi Alamsyah Putra4, Shariff Halim5

1Physiology Division, Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
2Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
3Department of Anatomy, Histology & Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
4Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
5Faculty of Health Sciences, University Technology MARA (UiTM) Pulau Pinang, Bertam Campus, 13200 Kepala Batas, Pulau Pinang, Malaysia

Response of Pro-Inflammatory Cytokines After A Single Bout of Moderate-Intensity Endurance Exercise in Obese

Sport Mont 2024, 22(1), 123-127 | DOI: 10.26773/smj.240217


Reducing the complications of obesity by controlling the balance of inflammation and losing weight with physical exercise can be used as a strategy to overcome obesity problems. This study aims to prove the effect of moderate-intensity endurance exercise on the acute response of proinflammatory cytokines in obese women. A total of 22 obese women aged 20-24 years, with body mass index 27-33 kg/m2, and body fat percentage ≥30%, were selected to be respondents and given moderate-intensity endurance exercise intervention (60-70% HRmax) for 40 minutes. ELISA Kit was applied to evaluate TNF-α levels in all samples. The data analysis technique uses an independent sample t-test with a significance level of 5%. The results show the average TNF-α levels between the control (CON) vs endurance exercise group (END) in pre-exercise (5.47±2.19 vs 5.39±1.45 pg/mL, p=0.932), post-exercise (5.76±2.08 vs 3.68±2.10 pg/mL, p=0.039), delta (value of pre-exercise – post-exercise) (0.29±2.27 vs -1.72±1.04 pg/mL, p=0.020). This study consistently proves that one session of moderate-intensity endurance exercise for 40 minutes reduces TNF-α levels in obese women.


endurance exercise, obesity, pro-inflammatory cytokines, sedentary lifestyle

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